Will Disabling IPv6 harm a Windows 8 or Server 2012 R2?

I have a script that was written for Windows 7 and server 2008. I would like to know if it was harm a Windows 8 or any build of Server 2012 box. If so, could you please list what it would harm.

It was create to help with speed issues for an older network based program.

Thanks in advance.

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netsh interface tcp set global autotuning=disabled

ocsetup MSRDC-Infrastructure /uninstall

@Echo off 
@ECHO Windows Registry Editor Version 5.00 > %TEMP%\DisableIPv6.reg
@ECHO [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Tcpip6\Parameters] >> %TEMP%\DisableIPv6.reg
@ECHO "DisabledComponents"=dword:ffffffff >> %TEMP%\DisableIPv6.reg 
@ECHO [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\LanmanServer\Parameters] >> %TEMP%\DisableIPv6.reg
@ECHO "Smb2"=dword:00000000 >> %TEMP%\DisableIPv6.reg 
REGEDIT /S %TEMP%\DisableIPv6.reg

ipconfig /flushdns

sc config CscService start= disabled

sc config lanmanworkstation depend= bowser/mrxsmb10/nsi

sc config mrxsmb20 start= disabled

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